Cardiac fibroblast-derived IGFBP6 orchestrates cardiac remodeling by coupling the EGR1-MFAP4 axis

作者：Shaopeng Cheng, Yilin Wang, Kunsheng Li, Xiaoting Wu, Qianwen Zhao, Tingting Tong, Jian Shi, Y. Xue, Jie Yang, Dongjin Wang · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.114417 · 被引用次数：5 · 研究领域：Cardiovascular Function and Risk Factors、Tissue Engineering and Regenerative Medicine、Cardiac Fibrosis and Remodeling

Our study identifies fibroblast-derived IGFBP6 as a novel regulator of cardiac fibrosis through the EGR1-MFAP4 signaling axis, driving myofibroblasts differentiation and adverse remodeling. Targeting this pathway may offer therapeutic potential for cardiac remodeling disorders.