Bringing p53 Back: A Prion-Powered Attack on Retinoblastoma

作者：Yuyan Ma, Siqi Yan, Weiming You, Peili Wang, Wangxiao He, Yao Yu, Xiaoqiang Zheng · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.113116 · 被引用次数：2 · 研究领域：Cancer-related Molecular Pathways、Cell death mechanisms and regulation、Hedgehog Signaling Pathway Studies

findings further confirm the transformative potential of this platform for tumor-specific p53 reactivation, potentially applicable to other neuroectodermal malignancies. Pri-MP thus holds promise as a next-generation modality for eye-preserving RB treatment, meriting further investigation in clinical settings to advance safer, more effective management of this devastating pediatric cancer.