LIFE-Moms: effects of multicomponent lifestyle randomized control trial on physical activity during pregnancy in women with overweight and obesity

作者：Hannah E. Cabre, Kimberly L. Drews, Jeremy Pomeroy, Sarah Kozey Keadle, S. Sonia Arteaga, Paul W. Franks, Debra Haire‐Joshu, William C. Knowler, F. Xavier Pi‐Sunyer, Linda Van Horn, Rena R. Wing, Alison G. Cahill, Rebecca G. Clifton, Kimberly A Couch, Dympna Gallager, Jami L. Josefson, Kaumudi Joshipura, Samuel Klein, Corby K. Martin, Alan M. Peaceman, Suzanne Phelan, Elizabeth Thom, Leanne M. Redman, Todd Hagobian, Andrew Schaffner, Chantelle N. Hart, Elaine Yin, Maureen G. Phipps, Barbara Abrams, Theresa O. Scholl, David A. Savitz, K. Munoz-Christian, Elissa Jelalian, Dympna Gallagher, Barak Rosenn, Charles Paley, Sonia Gidwani, Michelle Horowitz, Janet L. Crane, Susan Lin, J. Thornton, Mary Anne Holowaty, Isaiah Janumala, Jill L. Johnson, Tatiana Toro‐Ramos, Elisabeth Widén, Weihui Yu, Maribel Campos, María Angélica Trak‐Fellermeier, Marytere Meléndez, Cristina Palacios, Jeremy Pomeroy, Irma Febo, J. Vergara, Juan Á. Rivera, Kharla V.S. Mendez, Roxana Torres, Sandra Soltero, Laura Ramos, V. Rivera, Walter C. Willett, Matthew W. Gillman, Richard I. Stein, Amit Mathur, W. Todd Cade, Mary Kwasny, Linda J. Neff, Niki Gernhofer, Eileen Vincent, V. Vignolles, Bonnie Spring, K. Elkind-Hirsh, J. Breaux, Daniel S. Hsia, Jeffrey H. Burton, Lauren E. Cain, Abby D. Altazan, Elizabeth F. Sutton, L. Anne Gilmore, Jeffrey M. Curtis, Diana L. Dunnigan, Brian A. Grice, Robert L. Hanson, M. A. Hoskin, Karen Kavena, Carol Disbrow Moffett, Samantha Murphy, Jonas A. Nelson, Robert G. Nelson, Sandra Sangster, Jiaqiang Liao, Leigh A. Shovestull, Stephanie K. Tanamas, Rhys Williams, Trisha M. Boekhoudt, Mary E. Evans, Jack A. Yanovski, D. Lee Alekel, M. Miodovnik · 发表于：International Journal of Behavioral Nutrition and Physical Activity · 年份：2025 · DOI：10.1186/s12966-025-01805-9 · 被引用次数：3 · 研究领域：Gestational Diabetes Research and Management、Maternal Mental Health During Pregnancy and Postpartum、Pregnancy and preeclampsia studies

BACKGROUND: This report details the effect of LIFE-Mom's multicomponent lifestyle interventions on physical activity (PA) and inactivity time across pregnancy (2nd and 3rd trimesters) and their effect on gestational weight gain (GWG) and maternal/neonatal outcomes, a pre-specified secondary analysis. METHODS: were randomized to lifestyle interventions with dietary and PA counseling or standard care. PA and inactivity time measured by accelerometry and metabolic and inflammatory biomarkers measured in fasting blood are reported in 522 pregnant people at baseline and end of pregnancy. Generalized linear models with and without covariates were used to evaluate group differences (intervention vs. control) and, separately, time differences (total sample with both groups combined). RESULTS: Although there were statistically significant differences in vigorous activity between the intervention and control group (p = .024), there were no clinically meaningful differences in PA. In the combined sample, moderate to vigorous PA (MVPA) significantly decreased across pregnancy (mean ± SD: 72.9 ± 29.1 min/day vs 63.9 ± 28.1 min/day; p < 0.0001), and inactivity time increased [617.5 min/day (573.5, 659.6) vs 630.4 min/day (56.7, 679.9); p < 0.0001]. Increased inactivity time was associated with a less favorable maternal milieu (biomarker Z-scores) for pro-inflammatory (0.2 ± 0.1; p = 0.003) and cardiometabolic markers (0.1 ± 0.07; p = 0.030). CONCLUSIONS: Physical activity declined over the...