Curcumin Inhibits Bisphenol A-Induced Fat Mass Gain by Enhancing White Adipose Tissue Browning via Modulating Gut Microbiota-Dependent Bile Acid Metabolism in CD-1 Mice

作者：Xiaobing Chen, Xiaobing Chen, Jun Zou, Jun Zou, Zhuo Cao, Zhuo Cao, Ting Hong, Hongmin Zhang, Jie Yang, Haiyan Mai, Xin Li, Dan Feng · 发表于：Journal of Medicinal Food · 年份：2025 · DOI：10.1177/1096620x251383432 · 被引用次数：3 · 研究领域：Adipose Tissue and Metabolism、Adipokines, Inflammation, and Metabolic Diseases、Regulation of Appetite and Obesity

Chronic exposure to low-dose bisphenol A (BPA) has emerged as a pressing worldwide public health concern. Our previous work demonstrated that low-dose BPA exposure caused gut microbiota dysbiosis and liver fat accumulation. Curcumin is a polyphenol extracted from the rhizome of turmeric and has an inhibitory effect on liver fat accumulation and obesity. This study aimed to investigate the protective effects of curcumin against BPA-induced fat mass gain and obesity and gut microbiota-dependent bile acid (BA) metabolic mechanism. Male CD-1 mice were fed a diet containing a low dose of BPA (50 µg/kg/day) with or without 0.1% w/w curcumin for 24 weeks. Curcumin supplementation markedly decreased the fat mass of inguinal white adipose tissue (iWAT) and the ratio of iWAT weight to body weight in BPA-exposed mice. Curcumin-treated mice exhibited decreased Firmicutes/Bacteroidetes ratio and increased relative abundance of Bacteroides , Parabacteroides, and Akkermansia , which are related to BA metabolism. Moreover, serum levels of lithocholic acid, the most potent activator of Takeda G protein-coupled receptor 5 (TGR5), and TGR5 expression in iWAT were significantly increased following curcumin intervention. Activation of TGR5 elevated cyclic adenosine monophosphate levels, subsequently up-regulating the expression of iodothyronine deiodinase 2 and fibroblast growth factor 21. These changes increased the expression of uncoupling protein 1 (UCP1), ultimately leading to enhanced iWAT b...