Social determinants of health and biological age among diverse U.S. Adults, NHANES 2011–2018

作者：Robert A. Mesa, María M. Llabre, David Lee, Tatjana Rundek, Katrina Kezios, Adina Zeki Al Hazzouri, Tali Elfassy · 发表于：BMC Public Health · 年份：2025 · DOI：10.1186/s12889-025-23803-z · 被引用次数：3 · 研究领域：Health disparities and outcomes、Food Security and Health in Diverse Populations、Employment and Welfare Studies

BACKGROUND: Social determinants of health are fundamental drivers of health inequities. Education and income are inversely associated with accelerated aging, but less is known about differences in their association with aging by race/ethnicity. We examined the sex-specific association between each social determinant of health with biological age and by race/ethnicity. METHODS: Data were sourced from four two-year National Health and Nutrition Examination Survey cycles (2011–2018). Education and household income were self-reported. The Klemera-Doubal Method, an algorithm using biomarkers from different organ systems, was used to calculate biological age among 6,213 females and 5,938 males aged 30–75 years who were Mexican, other Hispanic, non-Hispanic White, non-Hispanic Black, non-Hispanic Asian, or other/multi-racial. We used multivariable linear regression models to determine the association between education and income and biological age. RESULTS: Compared with a college education, less than a high school education was associated with higher biological age by 3.17 years (95% CI: 1.69, 4.65) among females only; associations were strongest among non-Hispanic Black, other Hispanic, and non-Hispanic Asian female adults. Compared with an annual income of ≥$75,000, an income <$25,000 was associated with higher biological age by 4.94 years (95% CI: 3.40, 6.47) among males and 2.74 years among females (95% CI: 1.48, 4.00); associations were strongest among non-Hispanic White and n...