Clinical Implications of Low Cell‐Free DNA Fetal Fraction in Non‐Invasive Prenatal Testing: A Retrospective Cohort Study of 40,716 Pregnancies

作者：Kayono Yamamoto, Nobuhiro Suzumori, Kiyonori Miura, Takahiro Yamada, Yoshimasa Kamei, Hideaki Sawai, Haruka Hamanoue, Osamu Samura, Seiji Wada, Jun Murotsuki, Kiyotake Ichizuka, Reina Komatsu, Yukiko Katagiri, Hiroko Morisaki, Setsuko Nakayama, Kazuya Mimura, Yuko Matsubara, Yoko Okamoto, Kazuhisa Maeda, Shun Yasuda, Akinori Ida, Mika Ito, Hiromi Hayakawa, Arisa Fujiwara, なほ子 白土, Tatsuko Ishii, Haruhiko Sago, Akihiko Sekizawa · 发表于：Prenatal Diagnosis · 年份：2025 · DOI：10.1002/pd.6900 · 被引用次数：7 · 研究领域：Prenatal Screening and Diagnostics、Fetal and Pediatric Neurological Disorders、Pregnancy and preeclampsia studies

OBJECTIVE: This study aimed to investigate the association between fetal fraction (FF) on non-invasive prenatal testing (NIPT) and pregnancy-related complications using a large sample to support improved prenatal management. METHODS: This retrospective cohort study included women with singleton pregnancies and negative NIPT results between January 2015 and March 2022 as part of the Japan Multicenter Study. Chi-square tests and binary logistic regression analyses were used to assess the association between FF and pregnancy-related complications. RESULTS: (1) = 2.84, p = 0.09). Women in the low FF group (FF < 10.27%, < 25th percentile) had higher risks of fetal demise, adjusted OR = 1.79, 95% CI [1.31, 2.43]), preterm birth (adjusted OR = 1.63, 95% CI [1.30, 2.06]), fetal growth restriction (FGR) (adjusted OR = 1.50, 95% CI [1.10, 2.05]), and hypertensive disorders of pregnancy (HDP) (adjusted OR = 1.44, 95% CI [1.24, 1.66]). No significant differences were observed for gestational diabetes mellitus (GDM) (adjusted OR = 1.13, 95% CI [0.99, 1.30], p = 0.081). CONCLUSION: Low FF on NIPT is associated with an increased risk of several pregnancy complications, highlighting the need for careful management.