Silicon-Based Nanomaterials in Chronic Wound Healing: Mechanisms, Therapeutic Applications, and Clinical Prospects

作者：Xuan Zhao, Zezhou Xu, Dongfang Wang, Tao Li, Zhanfei Li, Xiangjun Bai, Hao Zhu, Yukun Liu, Yu-Chang Wang · 发表于：International Journal of Nanomedicine · 年份：2025 · DOI：10.2147/ijn.s528531 · 被引用次数：13 · 研究领域：Graphene and Nanomaterials Applications、Wound Healing and Treatments、Nanoparticles: synthesis and applications

Silicon-based nanosystems are emerging as promising nanotherapeutic platforms in the biomedical field, particularly for the treatment of chronic wounds. These materials possess several advantageous features. They offer excellent drug-loading capacity, controlled and stimuli-responsive drug release, and highly customizable structures and functions. These characteristics make them well-suited for personalized therapeutic approaches.This review provides a comprehensive summary of recent advances in the application of silicon-based nanosystems in wound healing. It highlights their mechanisms of action and discusses future development directions. We begin by outlining the clinical significance and complex pathophysiological characteristics of chronic wounds. A detailed classification of silicon-based nanomaterials is then provided, including mesoporous silica nanoparticles and silicon-based composites. The review emphasizes their key roles in modulating inflammation, reducing oxidative stress, and promoting angiogenesis and tissue regeneration. In addition, we summarize recent findings from in vitro and in vivo studies, as well as updates from relevant clinical research. The biocompatibility and safety profiles of these systems are also comprehensively evaluated. Future research should focus on optimizing the synthesis of these materials and improving their long-term biosafety. Efforts should also aim to integrate multifunctional therapeutic strategies to enhance efficacy and tran...