The strategy of vitamin supplementation in Chinese patients with gastric cancer after gastrectomy: a prospective cohort study

作者：D R Li, Ming Zhao, Xiaoliang Cheng, Zhisong Tao, Y. N. You, Yangyang Fu, Tingwen Wang, Jiaqing Huang, Xin Li, Xiaojie Bian, Wenxian Guan · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-18074-y · 研究领域：Folate and B Vitamins Research、Nutrition and Health in Aging、Diet and metabolism studies

This study investigated the effects of oral multivitamin supplementation on vitamin levels in Chinese gastric cancer patients after gastrectomy, aiming to provide a basis for postoperative vitamin supplementation strategies. A total of 78 patients who underwent radical gastrectomy were divided into an experimental group (41 patients, receiving oral multivitamins) and a control group (37 patients). Levels of folic acid, vitamin B 12 , vitamin B 1 , and 25-hydroxyvitamin D were compared before and one month after surgery. Results showed that the level of vitamin B 1 in the experimental group was substantially higher than that in the control group when comparing the difference value between the preoperative and 1-month postoperative periods ( P < 0.05). Although the deficiency rates of 25-hydroxyvitamin D and vitamin B 1 were relatively high in both groups, the vitamin B 1 deficiency rates of the experimental group 1 month postoperatively were significantly lower than preoperative rates ( P < 0.05). Subgroup analysis revealed that partial gastrectomy patients in the experimental group had increased vitamin B 1 levels and decreased deficiency rates compared to the control group ( P < 0.05). The study suggests that systematic multivitamin supplementation should be routinely administered to Chinese gastric cancer patients following gastrectomy, with particular emphasis on initiating vitamin B 1 and vitamin D supplementation upon resumption of semi-solid oral intake. Patients after ...