Effect and acceptability of different exercise modes on adult patients with clinically diagnosed depression: a network meta-analysis

作者：Siqi Zhang, Litao Yang, Jiawei Chen, Junli Wang, Gang Liu · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-14648-y · 被引用次数：2 · 研究领域：Mental Health Research Topics、Physical Activity and Health、Meta-analysis and systematic reviews

The global prevalence of depression continues to rise, making it a leading cause of suicide. Although evidence-based treatments for mental disorders exist, over 75% of affected individuals in low- and middle-income countries lack access to care. Consequently, cost-effective exercise interventions are increasingly recognized as viable therapeutic options. However, conclusive evidence comparing the relative efficacy and acceptability of different exercise modalities for alleviating depressive symptoms remains lacking. Therefore, this study employed a network meta-analysis to directly compare the relative efficacy and acceptability of various exercise interventions for individuals with depression. Adhering to PRISMA-NMA guidelines, a comprehensive literature search was conducted across seven electronic databases (PubMed, Cochrane Library, PsycINFO, Embase, CNKI, MEDLINE, and Web of Science) to identify randomized controlled trials (RCTs) examining exercise interventions for depression.Studies meeting the predefined inclusion criteria were selected for analysis.Methodological quality and risk of bias of the included studies were evaluated using the Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1).The quality of evidence derived from the network meta-analysis was assessed using the Confidence in Network Meta-Analysis (CINeMA) framework. Network meta-analysis was performed using Stata software (version 17.0). The final analysis included 58 articles (encompass...