Effect of -deficiency constitution on cognitive impairment in cerebral small vessel disease and its neuroimaging mechanism.

作者：Xin Liu, Yang Shuning, X U Yun · 发表于：PubMed · 年份：2025 · DOI：10.19852/j.cnki.jtcm.2025.05.019 · 被引用次数：1 · 研究领域：Neurological Disease Mechanisms and Treatments、Ginkgo biloba and Cashew Applications、Traditional Chinese Medicine Studies

OBJECTIVE: To explore the effect of Traditional Chinese Medicine (TCM) constitution on cognitive impairment (CI) in patients with cerebral small vessel disease (CSVD) and its underlying neuroimaging mechanism and to provide countermeasures for health management of CSVD patients. METHODS: A total of 241 CSVD patients were recruited from the Department of Neurology. All subjects underwent head magnetic resonance imaging (MRI), Chinese Medicine Questionnaire (CCMQ) and cognitive function examination. The CSVD patients were divided according to the Montreal Cognitive Assessment (MoCA) score into a normal cognitive group (73 cases) and a CI group (168 cases). Logistic regression was used to analyse the risk constitution of CSVD-CI and to construct a risk prediction model. 3DT1 MRI images and FreeSurfer 6.0 software (Athinoula A. Martinos, Boston, MA, USA) were used to further explore the involvement of hippocampal subregion volume in patients with at-risk constitution and its correlation with cognitive function. RESULTS: 0.05). CONCLUSION: CSVD patients with YADC are more prone towards developing CI, and asymmetric atrophy of the hippocampus might be the underlying neuroimaging mechanism. In particular, the volume of the left whole hippocampus and the left hippocampal molecular layer correlated significantly with general cognitive function.