Multispectral Chiral Quasi‐Bound States in the Continuum Enabled Microfluidics for High‐Throughput Molecular Screening and Quantification

作者：Xinyue Liang, Zihan Zhao, Xiaocong Tang, Haiyue Yang, Lanju Liang, Meng Zhao, Cong Wang, Lei Wang, Xumin Ding · 发表于：Advanced Science · 年份：2025 · DOI：10.1002/advs.202515443 · 被引用次数：4 · 研究领域：Spectroscopy and Quantum Chemical Studies、Advanced biosensing and bioanalysis techniques、Photonic and Optical Devices

Abstract Traditional chiral detection methods often suffer from label dependence and limited throughput, hindering accurate profiling of trace enantiomers. Herein, a terahertz (THz) multispectral metachip‐enabled microfluidic platform is presented for label‐free, high‐throughput screening and quantitation of chiral molecules. The metachip integrates arrayed pixels engineered with chiral quasi‐bound states in the continuum (q‐BIC), generating high circular dichroism (CD) across 0.5–2.0 THz. On‐chip microfluidic integration enables multi‐dimensional CD feature extraction in aqueous environments, while the Uniform Manifold Approximation and Projection (UMAP) algorithm maps multidimensional CD features into a Two‐dimensional (2D) spectrum, simultaneously realizing conformation identification and concentration quantification (0.05–0.3 mg dL −1 ). Experimentally, 87.5% discrimination accuracy is achieved for 8 chiral biomolecules in aqueous solutions (including amino acids and dipeptides) with state‐of‐the‐art sensitivity (2.1024 THz· mg 1 ·dL). This platform bridges the gap between high‐sensitivity chiral sensing and real‐time fluidic analysis, offering a transformative tool for trace enantiomer characterization in clinical diagnostics and drug development.