HBV and host metabolic crosstalk: Reprogramming pathways for viral replication and pathogenesis

作者：Yu Yan, Zhiqiang Wei, Min Zheng, Mengji Lu, Xueyu Wang · 发表于：Virologica Sinica · 年份：2025 · DOI：10.1016/j.virs.2025.09.008 · 被引用次数：5 · 研究领域：Liver Disease Diagnosis and Treatment、Epigenetics and DNA Methylation、Cancer, Hypoxia, and Metabolism

Hepatitis B virus (HBV) establishes chronic infection through strategic manipulation of host metabolic networks, driving a spectrum of hepatic pathologies ranging from hepatitis to cirrhosis and hepatocellular carcinoma. Mechanistically, HBV reprograms core metabolic pathways, including glycolysis, tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and lipid homeostasis, to fuel its replication machinery and evade immune surveillance. This review systematically synthesizes current evidence on HBV-induced glucose/lipid metabolic rewiring, with particular emphasis on how viral-host crosstalk at the metabolic interface sustains viral pathogenesis.