Immune cell dynamics and their role in cardiac injury: Mechanisms and therapeutic implications

作者：Chunlei Liu, Rihan Wu, Hao Yang, Yong-ming Yao · 发表于：Biomedicine & Pharmacotherapy · 年份：2025 · DOI：10.1016/j.biopha.2025.118608 · 被引用次数：15 · 研究领域：Vagus Nerve Stimulation Research、Neuroinflammation and Neurodegeneration Mechanisms、Cardiac Fibrosis and Remodeling

Cardiovascular injury initiates a temporally regulated immune cascade that governs both tissue damage and repair. Neutrophils, macrophages, dendritic cells, and T cells contribute distinct yet overlapping functions during acute inflammation, resolution, and chronic remodeling. This review synthesizes recent findings from single-cell transcriptomics, spatial omics, immunometabolism, and neuroendocrine–immune interactions to delineate immune cell dynamics across major cardiac diseases, including myocardial infarction, heart failure, viral myocarditis, hypertensive remodeling, and sepsis-induced cardiomyopathy. We further examine how immune cells communicate with cardiomyocytes, fibroblasts, endothelial cells, and neurohormonal regulators to shape the myocardial microenvironment. Particular emphasis is placed on macrophage polarization, regulatory T cell activity, extracellular vesicle–mediated signaling, and metabolic checkpoints as key determinants of immune behavior. Based on these mechanistic insights, we propose a framework for precision immunotherapy that integrates immune profiling, metabolic status, and neuroendocrine cues to guide individualized interventions. Emerging strategies—including low-dose interleukin-2, immune checkpoint blockade, mesenchymal stem cell–derived extracellular vesicles, and immunometabolic reprogramming—are highlighted as promising means to recalibrate immunity toward tissue repair. Overall, this review provides a translational perspective aimed ...