Gray matter microstructural abnormalities in temporal lobe epilepsy with hippocampal sclerosis and MRI negative

作者：Wenrui Yang, Jiandong Niu, Yuhui Xiong, Xucong Wang, Jian Li, Zhuo Wang, Dengyan Song, Bing Chen · 发表于：European Journal of Radiology · 年份：2025 · DOI：10.1016/j.ejrad.2025.112455 · 被引用次数：2 · 研究领域：Epilepsy research and treatment、Neuroscience and Neuropharmacology Research、Functional Brain Connectivity Studies

Objective To assess the changes of cortical microstructure in patients with temporal lobe epilepsy combined with hippocampal sclerosis (TLE-HS) and MRI-negative TLE (negative-TLE) and its correlation with clinical characteristics. Methods A total of 59 TLE-HS patients, 47 negative-TLE patients, and 67 healthy controls (HC) participated in this study. Gray matter-based spatial statistics (GBSS) analysis was performed using neurite orientation dispersion and density imaging (NODDI) data to compare differences in gray matter (GM) microstructure across the groups, including neurite density index (NDI), orientation dispersion index (ODI). Microstructural indicators were determined to be statistically significant using the threshold-free cluster enhancement method, and multiple comparisons were corrected using the family-wise error (FWE) method. P FWE < 0.05 was considered statistically significant. The correlation between the indicator values of significantly different brain regions and clinical characteristics was also analyzed. Results Compared with the HC group, TLE-HS exhibited widespread reductions in NDI and ODI values within GM, and these changes were primarily affecting the bilateral frontotemporal lobes and limbic system. In contrast to the negative-TLE group, the decrease in NDI in TLE-HS patients was more localized and showed partial lateralization. This decrease was most pronounced in the bilateral frontal pole, frontal gyrus, left temporal pole, temporal gyrus, parahi...