Genetic architecture of gastric adenocarcinoma in West Asia

作者：Saeid Latifi‐Navid, Esmat Abdi, Tianpei Wang, Farhad Pourfarzi, Abbas Yazdanbod, Seyed Alireza Salami, Reza Safaralizadeh, Omolbanin Amjadi, Hamid Latifi‐Navid, Bahareh Safarnejad, Mahmoud Shokrabadi, Iradj Maleki, Vahid Hosseini, Seyed Mohammad Valizadeh, Mehdi Pourghasemian, Negin Abediasl, Arash Kazemi, Mohammad Eslami Jouybari, Zohreh Bari, Tarang Taghvaei, Caiwang Yan, Amir Taher Eftekhar Sadat, Seyed Yaghoub Moaddab, Ghasem Janbabaei, Mohammad Hossein Somi, Alireza Sadjadi, Ramin Shakeri, Farideh Siavoshi, Hafez Fakheri, Hossein Poustchi, Reza Malekzadeh, Guangfu Jin · 发表于：Clinical and Translational Medicine · 年份：2025 · DOI：10.1002/ctm2.70489 · 被引用次数：1 · 研究领域：Helicobacter pylori-related gastroenterology studies

Dear Editor, Gastric cancer (GC) is a significant global health concern, with 968 000 new cases and 660 000 deaths in 2022, with male predominance.1 Despite a declining trend, the absolute number of GC cases is anticipated to rise, particularly in East and West Asia.2 Most genome-wide association studies (GWASs) have focused on East Asian populations,3, 4 leaving a gap in understanding the genetic contributions to GC risk in West Asia, particularly in countries like Iran, where GC incidence is notably high. Most of Iran's northern and northwestern regions are located in the GC belt of West Asia. Helicobacter pylori infection, high salt intake, and smoking are major risk factors, along with gastroesophageal reflux disease, which contributes to higher cardia GC rates.5 This study presents a GWAS analysis of 4095 Iranian samples from high-risk areas, with subsequent replication in a large Chinese dataset of 21 168 samples, aiming to delineate susceptibility loci associated with GC. The analysis strategy is thoroughly outlined in Figure 1A (Supporting Information Methods). Of 2061 patients, 1531 (74.3%) were male; among 2034 controls, 1503 (73.9%) were male. The average age (mean ± SD) was 65.8 ± 11.0 and 67.8 ± 10.9 years for the patients and controls, respectively (Table S1). After filtering and quality control, 3686 subjects (1880 cases and 1806 controls) with 9 159 468 genetic variants were retained in the GWAS dataset (Figure 1A). A quantile‒quantile plot did not show substa...