Organophotocatalytic Decarboxylative Allylation of Carboxylic Acids with Allylic Acetates

作者：C. Ju, Xiaoyu Liu, Yanzhe Shi, Yinlei Zhang, Teck‐Peng Loh, Peizhong Xie · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c03690 · 被引用次数：11 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Oxidative Organic Chemistry Reactions

We developed an acridine-catalyzed, metal- and base-free decarboxylative allylation of carboxylic acids with allylic acetates under mild conditions. The reaction proceeds via a proton-coupled electron transfer (PCET) process, enabling efficient conversion of readily available feedstocks with broad functional group compatibility. This operationally simple and versatile method demonstrates significant potential for synthetic applications, particularly in late-stage modification of bioactive carboxylic acids.