Antimicrobial Prophylaxis in Elective Orthopaedic Surgical Procedures at the Tertiary Care Hospital: A Prospective Observational Study

作者：Milica Kosić, Branislava Miljković, Vedrana Barišić, Sandra Vezmar Kovačević, Marija Jovanović, Katarina Vučićević, Tijana Kovačević · 发表于：Antibiotics · 年份：2025 · DOI：10.3390/antibiotics14100968 · 被引用次数：1 · 研究领域：Surgical site infection prevention、Orthopedic Infections and Treatments、Surgical Sutures and Adhesives

Objective: Surgical antimicrobial prophylaxis (SAP) is vital for preventing surgical site infections (SSIs). This study evaluated adherence to local SAP guidelines and assessed SSI-related risk factors in elective orthopaedic surgeries. Methods: A prospective observational study was conducted at a tertiary care hospital between August and October 2023. Patients were categorised into two groups: those receiving guideline-adherent SAP (SAP group) and those with inadequate SAP (ISAP group), defined by incorrect dosing or prolonged duration. Various patient- and procedure-related SSI risk factors were compared between groups. Results: Among 82 patients, 81 received SAP, but only a small proportion received it correctly. Most deviations were due to extended duration and incorrect dosing, resulting in 90.20% non-adherence. Despite this, no significant differences in known SSI risk factors were observed between the two groups, and no SSIs were reported during the study period. Conclusions: Non-adherence to SAP guidelines was widespread, mainly due to extended prophylaxis. Importantly, non-adherence was not associated with increased SSI risk, nor was it linked to higher baseline patient risk factors, suggesting that decisions were influenced more by clinical routine than by patient-specific risk. These findings emphasize the need to strengthen staff education and adherence to guidelines, thereby supporting antimicrobial stewardship in resource-limited settings.