Chronic Psychological Stress in Oncogenesis: Multisystem Crosstalk and Multimodal Interventions

作者：Bin Huang, Honglin An, Han‐Chung Wu, Yiman Qiu, Yanqing Su, Liming Chen, Vasiliki Georgakopoulou, Jiumao Lin, Wujin Chen, Ruofei Li, Dongliang Yang, Xiaojiaoyang Li, Demetrios�� Spandidos · 发表于：Research · 年份：2025 · DOI：10.34133/research.0948 · 被引用次数：20 · 研究领域：Cancer-related cognitive impairment studies

Malignant tumors constitute a major global public health burden. Chronic psychological stress (CPS) manifests as sustained dysregulation arising from prolonged adaptive responses to chronic endogenous and exogenous stimuli. Clinical evidence indicates that CPS markedly influences cancer progression, with most oncology patients developing detectable stress-related psychological disorders during disease management. This review synthesizes recent advances in understanding CPS-mediated oncogenic mechanisms and evaluates current intervention approaches. Mechanistically, CPS compromises immune surveillance through neuroendocrine-mediated hormonal dysregulation, impairing malignant cell recognition and clearance. Concurrently, CPS hormones promote tumor metabolic adaptation via hypothalamic-pituitary-adrenal axis-driven metabolic reprogramming, enhancing glycolytic flux to support uncontrolled proliferation. CPS further accelerates tumor progression through reactive oxygen species-induced mitochondrial impairment, DNA damage accumulation, and inflammatory cascades. Notably, CPS induces gut microbiota perturbations that reciprocally amplify tumorigenic processes through microbial metabolite disturbances and neuroimmune crosstalk, creating a self-perpetuating pathogenic loop. Therapeutic strategies to address cancer-related CPS that encompass pharmacological agents targeting neuroendocrine pathways, psychosomatic behavioral interventions, social environment adjustments, and evidence-b...