Burden of urogenital congenital anomalies: findings from the global burden of disease study 2021

作者：Yiwei Yue, Qian Zhang, Ji Li, Lei Wang, Lihua Guo, Quan Sun · 发表于：Frontiers in Pediatrics · 年份：2025 · DOI：10.3389/fped.2025.1584280 · 被引用次数：2 · 研究领域：Folate and B Vitamins Research、Pediatric Urology and Nephrology Studies、Birth, Development, and Health

Background: Urogenital congenital anomalies (UCAs) are among the most common organ system abnormalities in the neonate. This study employs Global Burden of Disease, Injury, and Risk Factor Study 2021 (GBD 2021) to systematically quantify the global epidemiological burden of UCAs from 1990 to 2021, examining geographic variations and temporal trends. Materials and methods: Data were extracted from the GBD 2021. We focused on UCAs-related metrics: prevalence, incidence, deaths, and disability-adjusted life years (DALYs) across 204 countries and territories, grouped into 5 or 21 GBD regions by the socio-demographic index (SDI). Data analysis encompassed relative change calculations, as well as annual percentage change (APC) and average annual percentage change (AAPC), both of which are based on joinpoint regression analysis. The study additionally employed decomposition analysis, frontier analysis and cross-country health inequality analysis. Analyses utilized R version 4.3.1. Results: From 1990 to 2021, the global prevalence of UCAs cases surged by 21%, exceeding 6.34 million, accompanied by an increase in age-standardized rates. Incidence, mortality, and DALYs experienced declines in both absolute figures and age-standardized rates. Gender-specific trends from 1990 to 2021 revealed that females dominated in prevalence, while males had higher mortality and DALYs burden. Regionally, Southern Sub-Saharan Africa exhibited the highest prevalence, while Oceania and East Asia showed ...