The Physiology of the WEight-Reduced State (POWERS) study: environmental, psychological, and social determinants of health

作者：Sai Krupa Das, Giada Benasi, John M. Jakicic, Wendy C. King, Susan Z. Yanovski, Stephanie Kelley, Laurel Mayer, Kathryn Whyte, Michael R. Lowe, Susan B. Roberts, Maren R. Laughlin, Dympna Gallagher, Rudolph L. Leibel, Laurel Mayer, Michael Rosenbaum, Maxine Ashby‐Thompson, Giada Benasi, Karin Foerde, Rochelle Goldsmith, Michio Hirano, Charles A. LeDuc, Christina A. Roberto, Heather Seid, Marie‐Pierre St‐Onge, Kathryn Whyte, Yiying Zhang, Alexis O. Aparicio, Daaimah Dratsky, Jing Gu, Michelle Horowitz, Susan Lin, Arden McMath, Cynthia Mikula, Joel Matos Nunez, Martin Picard, Janet Schebendach, Yifei Sun, Agnes Wong, Wenwen Yu, Bret H. Goodpaster, Susan B. Roberts, Michael R. Lowe, A.M. Autrán Gómez, Sophie Meierovich, Rachel Saks, M. Scharf, E. S. Williams, A. Ning Zhou, Olive Zhu, Kelly C. Allison, Matthew R. Hayes, Michael R. Rickels, David R. Roalf, Gary D. Wu, Payman Zamani, Lillian Chau, Adam Czernuszenko, Cassandra Demastus, Melissa Fernando, Kubarah Ghias, Gabrielle Grosso, Lindsay Herman, Nathaniel Holmes, Christina Mastracchio, Varsha Sayana, Nicholas Wellman, Sai Krupa Das, Roger A. Fielding, Andrew Howland, Kyle S. Burger, John R. Speakman, Catherine Hambly, Steven H. Belle, Wendy C. King, David Hallam, Tamara Haller, Stephanie Kelley, Christopher E. Kline, Kelsey R. Leonard, Andrew Pelesko, Matthew Zourelias, Panayiotis V. Benos, John M. Jakicic, Abdus S. Wahed, Kirk I. Erickson, NIH, Maren R. Laughlin, Yanovski, Bramaramba Kowtha, Deborah Lee Young-Hyman · 发表于：International Journal of Obesity · 年份：2025 · DOI：10.1038/s41366-025-01911-5 · 被引用次数：2 · 研究领域：Obesity, Physical Activity, Diet、Eating Disorders and Behaviors、Obesity and Health Practices

Intentional weight loss is often followed by unintentional weight regain. The causes of weight regain are uncertain but may include a myriad of responses that result in increased hunger and decreased energy expenditure. An individual's psychological state and social and physical environments are also thought to influence weight regain in ways that can either support or derail weight loss maintenance. Funded by the National Institutes of Health, the Physiology of the WEight Reduced State (POWERS) study is a multi-center clinical trial aimed at describing the molecular, cellular, physiological, behavioral, environmental and psychosocial factors that may be associated with an individual's ability to maintain their new weight after weight loss. This report provides the rationale for and describes the environmental, psychological and social determinants of health measures used in the POWERS study.