Immune checkpoint inhibitor-related myocarditis: a comprehensive analysis of clinical manifestations and prognostic factors

作者：Yue Fan, Yan Xu, Xiaoyan Liu, Guangcheng Liu, Bin Zhang, Wei Wu, Shuyang Zhang · 发表于：The Oncologist · 年份：2025 · DOI：10.1093/oncolo/oyaf285 · 被引用次数：7 · 研究领域：Cancer Immunotherapy and Biomarkers、Chemotherapy-induced cardiotoxicity and mitigation、Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

BACKGROUND: Immune checkpoint inhibitors-related myocarditis (ICI-myocarditis) is a rare but potentially lethal complication of cancer immunotherapy. Extensive information concerning risk factors and outcomes is still insufficient. METHODS: This multicenter retrospective study enrolled 161 patients diagnosed with biopsy-proven or clinically diagnosed ICI-myocarditis. We performed thorough studies of clinical characteristics and management approaches. Time-to-event analyses, encompassing landmark analysis, and competing risk models, were employed to identify early mortality predictors and evaluate long-term prognosis in survivors. RESULTS: ICI-myocarditis typically generally manifested early (median 4 weeks following ICI initiation), with mortality primarily occurring within 60 days. Significantly elevated cardiac troponin I (cTnI ≥ 50 times the upper reference limit) and reduced left ventricular ejection fraction (LVEF < 50%) were strong predictors of shortened survival. Landmark analyses revealed these factors influenced early but not long-term mortality beyond 60 days. Patients with concomitant myositis exhibited more fulminant presentations and higher early mortality, though long-term outcomes were comparable to those of isolated myocarditis. Multivariable analysis identified four independent predictors of cardiotoxicity-related death: initial LVEF < 50%, alanine aminotransferase (ALT), creatine kinase-MB (CKMB), and concomitant ICI-myositis. CONCLUSIONS: Our study identif...