Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations

作者：Sharmili Edwin Thanarajah, Adèle H. Ribeiro, Jae‐Hyun Lee, Nils R. Winter, Frederike Stein, Rachel N. Lippert, Ruth Hanßen, Carmen Schiweck, Leon Fehse, Mirjam Bloemendaal, Mareike Aichholzer, Aicha Bouzouina, Carmen Uckermark, Marius Welzel, Jonathan Repple, Silke Matura, Susanne Meinert, Corinna Bang, Andre Franke, Ramona Leenings, Maximilian Konowski, Jan Ernsting, L. Fisch, Carlotta Barkhau, Florian Thomas‐Odenthal, Paula Usemann, Lea Teutenberg, Benjamin Straube, Nina Alexander, Hamidreza Jamalabadi, Igor Nenadić, Andreas Lügering, Robert Nitsch, Sarah Kittel‐Schneider, John F. Cryan, Andreas Reif, Tilo Kircher, Dominik Heider, Udo Dannlowski, Tim Hahn · 发表于：JAMA Psychiatry · 年份：2025 · DOI：10.1001/jamapsychiatry.2025.2579 · 被引用次数：9 · 研究领域：Gut microbiota and health、Tryptophan and brain disorders、Nutritional Studies and Diet

Importance: Soft drink consumption is linked to negative physical and mental health outcomes, but its association with major depressive disorder (MDD) and the underlying mechanisms remains unclear. Objective: To examine the association between soft drink consumption and MDD diagnosis and severity and whether this association is mediated by changes in the gut microbiota, particularly Eggerthella and Hungatella abundance. Design, Setting, and Participants: This multicenter cohort study was conducted in Germany using cross-sectional data from the Marburg-Münster Affective Cohort. Patients with MDD and healthy controls (aged 18-65 years) recruited from the general population and primary care between September 2014 and September 2018 were analyzed. Data analyses were conducted between May and December 2024. Main Outcomes and Measures: Primary analyses included multivariable regression and analysis of variance (ANOVA) models examining the association between soft drink consumption and MDD diagnosis and symptom severity, controlling for site and education, and Eggerthella and Hungatella abundance, controlling for site, education, and library size. Mediation analyses tested whether microbiota abundance mediated the soft drink-MDD link. Results: A total of 405 patients with MDD (275 female patients [67.9%]; mean [SD] age, 36.37 [13.33] years) and 527 healthy controls (345 female controls [65.5%]; mean [SD] age, 35.33 [13.13] years) were included. Soft drink consumption predicted MDD d...