Remote ischaemic conditioning for preventing and treating ischaemic stroke

作者：Yue Qiao, Wen Hui, Sijie Li, Yuchuan Ding, Xunming Ji, Wenbo Zhao · 发表于：Cochrane Database of Systematic Reviews · 年份：2025 · DOI：10.1002/14651858.cd012503.pub3 · 被引用次数：3 · 研究领域：Cardiac Ischemia and Reperfusion、Cardiac and Coronary Surgery Techniques、Advanced Nanomaterials in Catalysis

RATIONALE: Remote ischaemic conditioning (RIC) has been innovatively utilised as a neuroprotective method in the prevention and treatment of stroke. RIC typically involves transiently restricting then restoring blood flow to limbs. The current evidence, as derived from various studies, indicates some beneficial effects of RIC, but also highlights the need for further investigation due to the presence of uncertainties and variations in study designs and outcomes. OBJECTIVES: To evaluate the benefits and harms of remote ischaemic conditioning in preventing and treating ischaemic stroke compared to sham or standard treatments. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, Web of Science, three Chinese databases, five trials registers, and conference proceedings, together with reference checking and citation searching. The latest search date was 11 March 2025. ELIGIBILITY CRITERIA: We included randomised controlled trials (RCTs) comparing RIC with sham RIC or standard medical management, over any length of follow-up, in people with ischaemic stroke. OUTCOMES: Our critical outcomes were mortality, recurrence of ischaemic stroke, and excellent functional outcome (Modified Rankin Scale (mRS) score 0-1). Our important outcomes were treatment-related adverse events, functional independence (mRS score 0-2), haemorrhagic stroke, stroke severity, improvement in neurological impairment, and cardiovascular events. RISK OF BIAS: We assessed risk of bias using the original Cochrane r...