A comprehensive analysis of magnetic resonance imaging and laboratory features in pyogenic, tuberculous, brucellar, and fungal spondylitis

作者：Weijian Zhu, Zhihao Xu, Sirui Zhou, Pengying Li, Fei Zhao, Gang Wu, Wei Xiong · 发表于：Quantitative Imaging in Medicine and Surgery · 年份：2025 · DOI：10.21037/qims-2025-605 · 被引用次数：1 · 研究领域：Spondyloarthritis Studies and Treatments、Infectious Diseases and Tuberculosis、Brucella: diagnosis, epidemiology, treatment

Background: Diagnosing infectious spondylitis is challenging due to overlapping clinical features and the lack of standardized diagnostic criteria. While magnetic resonance imaging (MRI) and laboratory findings are critical, studies simultaneously analyzing all four major types of infectious spondylitis remain non-existent. The aim of this study is to fill a critical gap in the current literature by providing the first comprehensive comparison of the MRI characteristics and laboratory data for the four major types of infectious spondylitis: pyogenic spondylitis (PS), tuberculous spondylitis (TS), brucellar spondylitis (BS), and fungal spondylitis (FS). Furthermore, the study aims to propose a decision tree model to assist clinical decision-making, particularly in cases where a biopsy may be delayed or unfeasible. This model is designed to facilitate earlier and more targeted interventions, ultimately leading to improved patient outcomes. Methods: In this retrospective study, we included 117 patients with confirmed infectious spondylitis (37 PS, 36 TS, 23 BS, and 21 FS) and an external test set of 34 confirmed cases. We analyzed MRI sequences including T2-weighted imaging (T2WI), short tau inversion recovery (STIR), and contrast-enhanced T1-weighted images (T1WI). Clinical and radiological features were assessed by two radiologists and two orthopedists. Statistical analysis was conducted using analysis of variance (ANOVA) and Kruskal-Wallis (K-W) tests. Five machine learning (...