Advances in physical and chemical strategies for dentin hypersensitivity therapy

作者：Xinru Li, Qihui Wang, Yirong Sun, Guoliang Wang, Congxiao Zhang, Jianxun Ding · 发表于：Journal of Advanced Research · 年份：2025 · DOI：10.1016/j.jare.2025.09.041 · 被引用次数：4 · 研究领域：Dental Erosion and Treatment、Pain Mechanisms and Treatments、Dental Anxiety and Anesthesia Techniques

BACKGROUND: Dentin hypersensitivity (DH) is a prevalent and acute dental pain disorder marked by a brief yet sharp toothache caused by exposed dentin, often in response to thermal, chemical, and mechanical stimuli. It significantly affects a person's quality of life, interfering with routine activities, such as eating and drinking. With an improved understanding of the mechanisms underlying DH, various physical and chemical strategies have been developed to alleviate the condition. AIM OF THE REVIEW: This review evaluates three principal mechanistic theories underlying DH desensitization, including the Direct Innervation Hypothesis, the Odontoblast Receptor Theory, and the Hydrodynamic Theory. It provides a detailed analysis of current physical, chemical, and synergistic therapeutic methods used for desensitization. Additionally, it discusses potential future therapeutic approaches for the treatments of DH. KEY SCIENTIFIC CONCEPTS OF REVIEW: This review highlights recent advancements and ongoing challenges in applying physical and chemical strategies for DH therapy. It also discusses potential future strategies and methods, offering insights into the prospects for the field.