Parental Mental Disorders and Offspring Mortality up to Middle Age

作者：Hui Wang, Krisztina D. László · 发表于：JAMA Psychiatry · 年份：2025 · DOI：10.1001/jamapsychiatry.2025.2572 · 被引用次数：2 · 研究领域：Maternal Mental Health During Pregnancy and Postpartum、Family Support in Illness、Child and Adolescent Psychosocial and Emotional Development

Importance: Parental mental disorders are associated with increased risks of infant mortality and with several developmental, mental, and somatic health outcomes, yet their associations with long-term morality in offspring remain unknown. Objective: To investigate the associations between parental mental disorders and the risk of mortality in offspring up to middle age. Design, Setting, and Participants: This nationwide register-based cohort study used data for individuals born in Sweden from January 1973 to December 2014. Data were analyzed from October 2024 to March 2025. Exposure: Parental mental disorders identified from the Patient Register. Main Outcomes and Measures: The outcomes were offspring mortality, including deaths due to any, natural, and unnatural causes, from birth up to December 31, 2023. Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% CIs for offspring mortality according to parental mental disorders. Cousin comparison analysis was performed to assess familial confounding due to genetic and shared environmental factors. Results: Among 3 548 788 offspring, 1 818 232 were male (51.2%; 635 213 exposed to parental mental disorders) and 1 730 556 were female (48.8%; 605 935 exposed to parental mental disorders). The mean (SD) age at index parental diagnosis was 15.8 (13.3) years. During a median (IQR) follow-up of 20.1 (11.5-32.5) years (age range at end of follow-up, 9-51 years), there were 12 725 deaths (7.93 per 10 000 person-...