Melatonin improved the outcomes of women with ART: a systematic review and meta-analysis of randomized trials

作者：Yi‐Lin Wu, Wenjie Huang, Li Tang, Yuelin Feng, Hongqing Chen, Mingxin Pan, Jinrong Peng, Chen Li, Huawei Wang · 发表于：Frontiers in Reproductive Health · 年份：2025 · DOI：10.3389/frph.2025.1680984 · 被引用次数：5 · 研究领域：Ovarian function and disorders、Reproductive Biology and Fertility、Reproductive Health and Technologies

Objective: To systematically evaluate whether the melatonin supplementation could improve the embryo development and pregnancy outcomes of infertile women undergoing assisted reproductive technologies (ART). Methods: This systematic review and meta-analysis followed the PRISMA guidelines and was prospectively registered in PROSPERO (CRD420251003042). The randomized controlled trials (RCTs) published before March 5, 2025 are included to evaluate the efficacy of melatonin on infertile women undergoing ART. Eligible studies reported at least one embryo development or pregnancy-related outcome. Primary outcome was clinical pregnancy rate; secondary outcomes including oocyte yield, fertilization rate, MII oocyte number, and high-quality embryo formation. Subgroup analyses were conducted based on stimulation protocols, melatonin dosage, and population characteristics. Risk of bias was assessed using the Cochrane Risk of Bias tool, and pooled effect sizes were calculated using fixed- or random-effects models depending on heterogeneity. Totally, eleven RCTs with a total of 1,481 participants were analyzed here. Data sources: PubMed/MEDLINE, Embase, and Cochrane Library. Results: Melatonin supplementation significantly improved clinical pregnancy rate (OR = 1.59, 95% CI: 1.22-2.07). Regarding embryo development, melatonin significantly increased the number of high-quality embryos (MD = 0.43, 95% CI: 0.07-0.79), MII oocyte (SMD=0.99, 95% CI: 0.29-1.69), and fertilization rates (OR = 1....