Clinical Value of Serum Procalcitonin in the Early Diagnosis of Peritoneal Dialysis‐Associated Gram‐Negative Bacterial Peritonitis

作者：Ye Liu, Tian Tian, Jin Xing, Yi Shao, Zhi-Hui Guo · 发表于：Therapeutic Apheresis and Dialysis · 年份：2025 · DOI：10.1111/1744-9987.70074 · 被引用次数：1 · 研究领域：Dialysis and Renal Disease Management、Sepsis Diagnosis and Treatment、Streptococcal Infections and Treatments

OBJECTIVE: This study investigated the value of procalcitonin in the diagnosis of Gram-negative (G-) bacterial peritonitis associated with peritoneal dialysis. METHODS: A total of 195 patients were divided into the G- (55 cases) and G+ bacterial infection groups (140 cases). The data were compared between the two groups. RESULTS: The most common species in the G- group was Escherichia coli (16.92%) and in the G+ group was Staphylococcus epidermidis (28.21%). Women were more likely to develop G- bacteria-infected peritoneal dialysis-associated peritonitis (PDAP) compared to the G+ bacteria-infected group (P < 0.01). The procalcitonin (P < 0.001), C-reactive protein (CRP) (p = 0.005), and number of nucleated cells before treatment (P < 0.001) were significantly increased, while the absolute level of blood lymphocytes was decreased (p = 0.01) in the G- bacteria group. Multivariate logistic regression analysis revealed that female gender (P < 0.001), low absolute values of lymphocytes (p = 0.011), elevated procalcitonin (p = 0.038), elevated CRP (p = 0.008), and elevated number of nucleated cells before treatment (p = 0.002) were independent risk factors for G- bacteria-infected PDAP. The combination of the five indicators had the greatest predictive value for the occurrence of G- bacteria-infected PDAP with a ROC of 0.821 (P < 0.001). CONCLUSION: An elevated serum PCT level, female gender, high number of nucleated cells before treatment, elevated serum CRP level, and low serum a...