Epithelial remodeling associated with corneal power and corneal higher-order aberrations after ray-tracing guided FS-LASIK for myopia

作者：Jiayu Li, Yuyan Huang, Yanzheng Song, Yushan Xu, Yixin Zhang, J. Wen, Zecheng Wang, Fengju Zhang · 发表于：Photodiagnosis and Photodynamic Therapy · 年份：2025 · DOI：10.1016/j.pdpdt.2025.105230 · 被引用次数：4 · 研究领域：Corneal surgery and disorders、Ophthalmology and Visual Impairment Studies、Glaucoma and retinal disorders

• Central epithelium exhibited minimal thickening following RG FS-LASIK • No significant difference in ET remodeling between astigmatism axes was observed • TCRP gradient reflecting spherical aberration control was linked to ET distribution • Pronounced paracentral ET remodeling related to HOAs requires continuous monitoring To evaluate epithelial remodeling, corneal power distribution and corneal higher-order aberrations (HOAs) after ray tracing-guided femtosecond laser-assisted in situ keratomileusis (RG FS-LASIK) for myopia. 66 eyes from 33 patients were included in this 6-month observational case series. Epithelial thickness (ET), total corneal refractive power (TCRP), corneal HOAs, corneal volume (CV), and Quality of Vision questionnaire were assessed. Concentrical TCRP gradient was calculated (△Km n = Km n+1 - Km n ). ET in 0-2 mm only increased by 2.97 ± 4.57 μm with the myopic correction of - 6.24±1.78 D. No difference between steep and flat meridians was identified ( P > 0.050). Km maintained a rate of decline in 1-3 mm and gently raised across 4-6 mm. ET thickening in 2-5 mm showed positive associations with TCRP gradient ( r of △Km 3 , △Km 4 , and △Km 5 were 0.304, 0.399, and 0.357; all P < 0.050). And greater mean and inferior remodeling in this annulus were related to increased spherical aberration and vertical coma at 6 mm ( r = 0.414 and -0.505; both P < 0.001), correspondingly severer focusing difficulties and milder double vision occurred ( coef = 8.665 and 3...