Impact of timeline-based management on treatment efficiency and outcomes in acute ischemic stroke: a quasi-experimental study

作者：Yufeng Li, Guo-Qin Feng, Yingfang Ao, Bin Gu, Jun Wang, Ai-Fang Xiao, Jianquan You · 发表于：Annals of Medicine · 年份：2025 · DOI：10.1080/07853890.2025.2561793 · 被引用次数：5 · 研究领域：Acute Ischemic Stroke Management、Stroke Rehabilitation and Recovery、Antiplatelet Therapy and Cardiovascular Diseases

Objective This study evaluated the impact of a timeline-based management protocol on treatment efficiency and short-term outcomes in acute ischemic stroke (AIS) patients.Methods A quasi-experimental study compared two cohorts treated at a single emergency department: a control group (n = 138) receiving conventional care (January–June 2022) and an intervention group (n = 125) managed with a timeline-based protocol (August–December 2022). Key metrics included door-to-needle time (DTN), admission-to-puncture time, order-to-CT time, and order-to-platelet-result time. Thrombolysis rates, Glasgow Outcome Scale (GOS), Fugl-Meyer scores, and stroke-specific quality of life were also analyzed.Results The intervention group showed significantly shorter DTN, puncture, CT, and platelet result times (p < 0.05), along with a higher thrombolysis rate. Significant improvements were also observed in GOS, motor function, and quality of life scores (p < 0.05).Conclusion The timeline-based protocol, featuring parallel coordination and a rapid-response stroke team, reduced treatment delays and improved clinical outcomes in AIS patients. These results support the adoption of time-sensitive protocols to enhance stroke care efficiency and prognosis.