Insights into O-GlcNAcylation and programmed cell death in cancer

作者：Xiaohan Yan, Wenhao Ren, Zhuang Zhu, Shaoming Li, Rui Shi, Kai Sun, Keqian Zhi, Ling Gao, Jingjing Zheng · 发表于：Frontiers in Cell and Developmental Biology · 年份：2025 · DOI：10.3389/fcell.2025.1560491 · 被引用次数：3 · 研究领域：Glycosylation and Glycoproteins Research、Galectins and Cancer Biology、Carbohydrate Chemistry and Synthesis

O-GlcNAcylation is an essential post-translational modification that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to numerous proteins' serine or threonine residues. Several studies have indicated O-GlcNAcylation regulates various processes related to cancer, including signal transduction, transcription, cell division, metabolism, and cytoskeletal regulation. Programmed cell death (PCD) is a regulated and organized form of cell death controlled by genes, including apoptosis, autophagy, pyroptosis, necroptosis, and ferroptosis. As research on PCD has become increasingly in-depth, a potential link between O-GlcNAcylation and PCD has emerged. This review will focus on the complex relationships between O-GlcNAcylation and different PCD pathways, which are closely tied to the onset, progression, and resistance of cancer. By clarifying the relationship between O-GlcNAcylation and PCD, we aim to create a theoretical basis for improving anti-cancer treatments, with promising potential for clinical application.