Palladium-Catalyzed Asymmetric Carbonylation of Alkynes to Axially Chiral Carbothioate Esters

作者：Yao Wang, Yang Yuan, Ting Yang, Yong‐Gui Zhou, Xiao‐Feng Wu · 发表于：Journal of the American Chemical Society · 年份：2025 · DOI：10.1021/jacs.5c11864 · 被引用次数：19 · 研究领域：Axial and Atropisomeric Chirality Synthesis、Catalytic C–H Functionalization Methods、Asymmetric Synthesis and Catalysis

High Resolution Image Download MS PowerPoint Slide Herein, we report a novel palladium-catalyzed asymmetric hydrothioesterification of alkynes under mild conditions, enabling the precise construction of axially chiral carboxylic thioester derivatives with excellent yields, regioselectivity, E / Z selectivity, and enantioselectivity. Disulfides and thiosulfonates were applicable, as well.