Personalized aerosolized bacteriophage treatment of a pulmonary infection due to carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae in an infant

作者：Huiyuan Yan, Nannan Wu, Jinlan Zhou, Anjie Jin, Mengjun Cheng, Jianfang Liu, Qian Yang, Chuanqing Wang, Leiyan He, Weiming Chen, Yixue Wang, Zhenyu Zhang, Caiyan Zhang, Weili Yang, Guoping Lu, Gangfeng Yan · 发表于：International Journal of Infectious Diseases · 年份：2025 · DOI：10.1016/j.ijid.2025.108075 · 被引用次数：5 · 研究领域：Bacteriophages and microbial interactions、Antibiotic Resistance in Bacteria、Vibrio bacteria research studies

A 9-month-old ICU patient with persistent carbapenem-resistant Acinetobacter baumannii pneumonia developed a secondary infection of carbapenem-resistant Klebsiella pneumoniae. A customized, preoptimized phage cocktail was administered twice daily for 3 consecutive days, resulting in eradication of the pathogens and reduction in their abundance in the lung and gut microbiota.