Recent advances in photo-induced synthesis of polycyclic quinazolinones from unactivated alkene-tethered quinazolinones

作者：Yuxin Luo, Fan‐Lin Zeng, Teck-Peng Loh, Zhenhua Jia · 发表于：Organic & Biomolecular Chemistry · 年份：2025 · DOI：10.1039/d5ob01231g · 被引用次数：11 · 研究领域：Quinazolinone synthesis and applications、Multicomponent Synthesis of Heterocycles、Phenothiazines and Benzothiazines Synthesis and Activities

radical cascade cyclization or intramolecular hydroarylation of unactivated alkene-tethered quinazolinone precursors. These methods are systematically categorized into four distinct classes based on the photocatalytic system employed: metal-based photocatalysts, organic photocatalysts, semiconductor photocatalysts, and photocatalyst-free conditions. Mechanistic insights and substrate scope are discussed in detail to highlight the synthetic versatility and limitations of each approach. Furthermore, future directions are outlined, including the development of recyclable photocatalytic systems, substrate engineering, and the use of environmentally benign solvents. We hope this review will serve as a comprehensive and practical resource for researchers engaged in the synthesis of quinazolinone-based heterocycles and related photochemical transformations.