A Near-Infrared-II Molecular Probe for Early Diagnosis of Acute Kidney Injury Induced by Diverse Etiologies

作者：Yiqi Zhu, Dingyuan Yan, Junyong Zhu, Hongbo Xü, Weijie Zhang, Jianquan Hou, Dong Wang, Ben Zhong Tang · 发表于：ACS Nano · 年份：2025 · DOI：10.1021/acsnano.5c09246 · 被引用次数：8 · 研究领域：Acute Kidney Injury Research、Lanthanide and Transition Metal Complexes、Renal and Vascular Pathologies

Acute kidney injury (AKI) is a clinical syndrome characterized by complex etiologies and usually lacks obvious clinical manifestations at the early stage. Compared with traditional imaging methods, optical imaging is broadly considered to be a promising technique for diagnosis of kidney dysfunction own to the merits of noninvasiveness, high sensitivity and fast feedback speed. Herein, we report a renal-clearable fluorophore, PEG-TBSe, for in vivo imaging across diverse AKI models in the second near-infrared (NIR-II, 1000-1700 nm) window. Notably, PEG-TBSe possesses an ultrasmall size (∼5.5 nm) that is suitable for renal clearance, allowing for comprehensive assessment of AKI severity in prerenal, renal and postrenal models. In addition, the real-time imaging capacities of PEG-TBSe are sensitive to early changes in AKI, enabling the noninvasive identification of renal lesions earlier than common clinical assays. Overall, this study demonstrates an effective NIR-II small molecular probe for the early diagnosis and evaluation of the severity of kidney dysfunction in different AKI models.