Population‐Based Study on the Coexistence of Metabolic Dysfunction‐Associated Steatotic Liver Disease and Chronic Kidney Disease

作者：Rachel Sze Jen Goh, Jaycie Koh, Made Ayu Utami Intaran, Yip Han Chin, Gwyneth Kong, Bryan Chong, Jobelle Chia, Mark Y. Chan, Anurag Mehta, Mark Muthiah, Muhammad Shahzeb Khan, Nicholas Chew · 发表于：Journal of the American Heart Association · 年份：2025 · DOI：10.1161/jaha.125.041834 · 被引用次数：15 · 研究领域：Liver Disease Diagnosis and Treatment、Chronic Kidney Disease and Diabetes、Liver Disease and Transplantation

Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) and chronic kidney disease (CKD) are important cardiovascular risk factors. However, the prognostic impact of coexisting MASLD and CKD remains understudied. Methods This study cohort used the NHANES (National Health and Nutrition Examination Survey) 2007 to 2018 database, examining outcomes in adults with varying MASLD and CKD statuses. The primary outcome was all‐cause mortality. Secondary outcomes included coronary heart disease, heart failure, stroke, and cancer. Cox regression model was constructed to investigate the relationship between MASLD/CKD and all‐cause mortality, adjusted for age, prior coronary heart disease, body mass index, smoking, poverty‐to‐income ratio, lipid‐lowering and glucose‐lowering medications. Sensitivity analysis was performed with hepatic fibrosis and CKD. Results Among 14 818 participants (mean follow‐up: 6.9 ± 3.4 years), a majority of participants had MASLD(−)/CKD(−) (50.8%), followed by MASLD(+)/CKD(−) (34.8%), MASLD(+)/CKD(+) (7.7%), and MASLD(−)/CKD(+) (6.7%). MASLD(+)/CKD(+) (n = 1142) had the highest rates of obesity (77.6%), hypertension (77.5%), dyslipidemia (67.0%), and diabetes (49.7%), with the highest risk of coronary heart disease (risk ratio [RR], 1.79 [95% CI, 1.13–2.82], P = 0.013) and heart failure (RR 2.33 [95% CI, 1.07–5.08], P = 0.033). Socioeconomic disparities were observed, with lower‐income individuals predominantly in the group with MASLD(+)/CKD...