Independent and joint relationships of physical activity and pulmonary function with the risk of all-cause mortality

作者：Jingxin Ma, Can Shen, Yu Jia, Rong Yang, Shanye Yi, Yiheng Zhou, Rui Zeng, Zhi Wan, Qian Zhao, Yi Lei, Xiaoyang Liao · 发表于：BMJ Open Respiratory Research · 年份：2025 · DOI：10.1136/bmjresp-2024-002818 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Long-Term Effects of COVID-19、Exercise and Physiological Responses

BACKGROUND: Physical activity (PA) plays a crucial protective role in the overall health outcomes of individuals with chronic obstructive pulmonary disease. However, accurate recommendations for amount and categories of PA are still unclear for individuals with impaired pulmonary function (PF) in community environments. Thus, this study aims to investigate the independent and joint relationships of PA and PF with mortality. METHODS: In a prospective UK Biobank cohort study, PA was collected by touchscreen questionnaires, and metabolic equivalents of task (MET)-minutes/week of total exercise was calculated by walking plus moderate-intensity PA plus vigorous-intensity PA. According to the standard of the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) 2024, GOLD stage 1, GOLD stage 2 and GOLD stages 3-4 were classified as mild, medium and severe PF impairment, respectively. Cox regression was established to analyse the association between PA, PF and the risk of all-cause mortality. RESULTS: A total of 354 572 participants were included with mean age of 56.0 years. Compared with lowest quintile of PA, highest quintile of PA was associated with lower risk of mortality in individuals with normal PF (HR=0.828), mild (HR=0.768), medium (HR=0.697) and severe PF impairment (HR=0.588). Generally, PF impairment related to mortality, and this relationship was independent of PA (p<0.05), except for individuals adhering to third quintile (1378-2340 MET-minutes/week) of P...