Discoidin domain receptor tyrosine kinase 2: A new perspective on microenvironment remodeling and targeted therapy of solid tumors (Review)

作者：Tong Lu, Huiying Guo, Hang Gong, Yaohui Ma, Yonggang Tian, Dekui Zhang · 发表于：Oncology Letters · 年份：2025 · DOI：10.3892/ol.2025.15279 · 被引用次数：2 · 研究领域：Cell Adhesion Molecules Research、Monoclonal and Polyclonal Antibodies Research、HER2/EGFR in Cancer Research

Cancer is one of the major areas on which global medical research and treatment development are currently focused. There has been an increasing incidence of several types of cancer, such as breast cancer, pancreatic cancer, uterine cancer, prostate cancer, liver cancer, kidney cancer, human papillomavirus-associated oral cancer and melanoma. Advancements in biomedical research have expanded treatment options for numerous cancers; however, an ideal or definitive cure remains elusive. Therefore, identifying novel targets for cancer treatment has become a major area of research in biomedicine. Due to its involvement in several human diseases and tumor progression, discoidin domain receptor tyrosine kinase 2 (DDR2) has attracted considerable attention. The present review synthesizes findings from previous studies and highlights the recent advances in DDR2 research, assesses its role across different types of tumors and evaluates its emerging significance in multiple biomedical fields.