Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy (Adv. Sci. 35/2025)

作者：Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu · 发表于：Advanced Science · 年份：2025 · DOI：10.1002/advs.71643 · 被引用次数：30 · 研究领域：Nanoplatforms for cancer theranostics、Nanoparticle-Based Drug Delivery、Advanced Nanomaterials in Catalysis

Cancer Vaccines In the Research Artikel (DOI: 2416756), Jun Zhao, Mi Liu, and co-workers investigate adjuvants, collection, lysis, purification, oxidation, loading sites, sizes etc. to maximize the efficacy of cancer vaccines. The optimized cancer nanovaccines loading whole tumor antigens can cure most tumor-bearing mice in multiple mouse cancer models. The landscape of immune cells in the blood, splenocytes, and draining lymph nodes of vaccine-treated mice are studied.