Identification and genetic evolutionary analysis of goose circovirus in Shandong and neighboring provinces in China in 2024

作者：X. B. Yang, Yifan Wang, Peng Wu, Tao Zhu, Shuzheng Zhang, Xiaoyu Yang, Xiangfeng Meng, Ziping Jiang, Yuze Lu, Zhangyong Ning, Xiaowei Wu, Xingdong Song, Shijin Jiang, Liangmeng Wei · 发表于：Poultry Science · 年份：2025 · DOI：10.1016/j.psj.2025.105826 · 被引用次数：3 · 研究领域：Animal Virus Infections Studies、Bacteriophages and microbial interactions、Viral gastroenteritis research and epidemiology

• GoCV reference strains isolated from geographically adjacent regions exhibit high sequence homology, indicating the presence of extensive regional transmission pathways. • Multiple GoCV subtypes coexist within the same geographic region, and certain strains demonstrate notable genetic divergence. • The high homology between GoCV isolates from ducks and the experimental strains further confirms that recombination events and cross-species transmission of circoviruses occur frequently among avian species. Goose circovirus (GoCV), a significant pathogen impacting waterfowl health, has led to significant economic losses in the goose industry. Since it was first identified in Germany in 1999, it has spread globally. To investigate the prevalence, genetic characteristics, and variation patterns of GoCV in Shandong and its neighboring provinces in China, this study used PCR to screen GoCV-positive samples collected from diseased geese in Shandong, Hebei, Henan, and Anhui provinces. Ten positive samples were selected for whole-genome amplification and sequencing. The results revealed that the nucleotide sequence homologies of the entire genome, the Rep gene, and the Cap gene of the 10 GoCV strains varied in the ranges of 96.9–99.5%, 96.6–99.7%, and 96.8–99.3%, respectively; furthermore, the amino acid sequence homologies were observed to fall in the ranges of 94.4–99.3%, 99.3–100%, and 98.0–100%, respectively. The 10 GoCV isolates showed high homology with reference strains from Anh...