Trends in hypertensive heart disease-related mortality among population with Alzheimer’s in the United States: a 22-year nationwide analysis

作者：Allahdad Khan, Tehreem Asghar, Laiba Yumn, Saniya Ishtiaq, Muhammad Saeed, Rabiah Aslam Ansari, Meenab Fatima, Mohamed Antar, Mobeen Z. Haider, Mubeena Laghari · 发表于：Annals of Medicine and Surgery · 年份：2025 · DOI：10.1097/ms9.0000000000003920 · 被引用次数：1 · 研究领域：Dementia and Cognitive Impairment Research、Blood Pressure and Hypertension Studies、Sodium Intake and Health

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder, while hypertensive heart disease (HHD) is a major cardiovascular condition linked to chronic hypertension (HTN). HTN is common among patients with AD, significantly impacting mortality. This study explores trends in HHD-related mortality among patients with AD in the US from 1999 to 2020, utilizing the Centers for Disease Control and Prevention's Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database. Methods: Data from the CDC WONDER database were used to extract mortality information for individuals aged ≥65 years, with AD and HHD as the underlying or contributing causes of death. Mortality rates were analyzed by age, sex, race/ethnicity, urban-rural classification, and region. Both crude- and age-adjusted mortality rates (AAMRs) were calculated. Joinpoint regression was employed to identify significant trends and changes in mortality over time. Results: HHD-associated mortality among patients with AD showed a significant upward trend, with deaths rising from 710 in 1999 to 3263 in 2020. The AAMR increased from 2.08 per 100 000 in 1999 to 6.26 per 100 000 in 2020, a threefold increase. Female patients had higher mortality rates than males throughout the study period. The highest mortality rates were observed in the age group of 85+ years, with notable regional disparities, particularly in the South and Midwest. The COVID-19 pandemic in 2020 contributed to a marked spike in m...