Epidemiology of Human Metapneumovirus (HMPV) in India: a cross-sectional study

作者：Rizwan Suliankatchi Abdulkader, Neetu Vijay, Varsha Potdar, Joshua Chadwick, Jitendra Narayan, R. Sabarinathan, Devika Shanmugasundaram, S. Sivaprakasam, Manoj Murhekar, Nivedita Gupta, Muthusamy Ravi, S. Palanisamy, S. Kalaivani, Swetha Durai, Sendhilkumar Muthappan, G. C. Mohan Kumar, Sumit Dutt Bharadwaj, Labanya Mukhopadhyaya, Sugumari Chandrasegaran, Sundararajan Thangavel, Girija Kannan, Bharathi Santhose, N. Prabakaran, Vinoth Madhavan, Krupa Chandran, Mohammed Razik Chinnan Abdul Razak, Veena Vipat, Sheetal Jadhav, Divya R. Bhattad · 发表于：The Lancet Regional Health - Southeast Asia · 年份：2025 · DOI：10.1016/j.lansea.2025.100667 · 被引用次数：5 · 研究领域：Respiratory viral infections research、Pneumonia and Respiratory Infections、Delphi Technique in Research

Background: The Department of Health Research, Ministry of Health and Family Welfare, India, established the Virus Research and Diagnostic Laboratory Network (VRDLN) in 2014 to strengthen viral diagnostic capabilities and provide a system for routine virological surveillance. In 2022, we also initiated the Model for Integrated Influenza Surveillance in Tamil Nadu (MIST) to enhance surveillance of virologic and clinical characteristics of severe acute respiratory infections (SARI) cases in selected sentinel tertiary care hospitals. This study investigates the epidemiology of Human Metapneumovirus (HMPV) in India by analysing data from these distinct but related surveillance systems. Methods: We analysed VRDLN data from 2019 to 2024 to describe HMPV cases based on time, place, and personal characteristics. We presented a comparison of two periods-2019 to 2023 and 2024-to compare historical trends with the current scenario. We also examined detailed clinical and laboratory profiles of HMPV-positive SARI cases collected under the MIST project from 2022 to 2024 (a case series). Hospitals under the VRDLN conducted testing of any physician-referred patient, while MIST exclusively tested SARI patients who met a standardised case definition. While the VRDLN provided an overall picture of the testing and positivity trends, MIST provided details on laboratory parameters, and clinical course and outcomes of positive cases. All laboratories adhered to standardised quality-assured testing ...