Mycobacterium tuberculosis infection status and associated factors among household close contacts of rifampicin-resistant pulmonary tuberculosis patients: A single-center cross-sectional study

作者：Zhengyu Shi, Juan Peng, Xiu Li, Xiaoyan Fu, Li‐Ping Zou, Qin Chen, Tao Huang, Yu Zhou, Hongmei Zhu, Yi Wang, Shenjie Tang, Guihui Wu · 发表于：Journal of Clinical Tuberculosis and Other Mycobacterial Diseases · 年份：2025 · DOI：10.1016/j.jctube.2025.100561 · 被引用次数：2 · 研究领域：Tuberculosis Research and Epidemiology、Diagnosis and treatment of tuberculosis、Mycobacterium research and diagnosis

Rifampicin-resistant tuberculosis (RR-TB) is a major global public health challenge. Household close contacts (HHCs) of RR-TB patients face a high risk of Mycobacterium tuberculosis infection. Southwestern China carries a heavy RR-TB burden, yet research data on the infection status of this population remain scarce. This study aimed to evaluate the incidence of latent tuberculosis infection (LTBI) and active tuberculosis disease (TBD) and their associated factors among HHCs of RR-TB patients in this region through active screening, providing data support for optimizing regional RR-TB prevention and control strategies. Using a cross-sectional design, HHCs of RR-TB patients diagnosed at Chengdu Public Health Clinical Medical Center from October 1, 2023, to March 30, 2025, were enrolled. Clinical data were collected via a self-designed questionnaire including gender, age, body mass index (BMI), relationship to index case, living environment, chronic comorbidities, medication history, and TBD-suspicious symptom screening. TBD screening used chest digital radiography (DR) or computed tomography (CT). Clinical data of index cases were extracted from the hospital information system (HIS), covering sputum acid-fast bacillus smear, sputum mycobacterial culture, sputum molecular testing for M. tuberculosis, fluoroquinolone resistance, extent of pulmonary lesions, and cavitation status. TB infection screening employed tuberculin skin test (TST), ESAT6-CFP10 fusion protein skin test (EC)...