Neutrophil-to-albumin ratio: a novel predictor of osteoporosis in rheumatoid arthritis

作者：Yifang Zhang, Zhongyu He, Kaiqiang Li, Qiuping Wu, Shigang Wang, Minying Liu, Qingping Liu, Qiang Xu, Xiangying Kong, Changsong Lin · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2025.1666884 · 被引用次数：3 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Statistical Methods in Epidemiology、Rheumatoid Arthritis Research and Therapies

Background: Osteoporosis (OP) frequently coexists with rheumatoid arthritis (RA), but validated predictors of early risk are not extensively studied. This study seeks to examine the relationship between the neutrophil percentage-to-albumin ratio (NPAR) and the likelihood of developing RA-related OP(RA-OP). Methods: After investigating the relationship between the NPAR and RA-OP in the clinical retrospective study, we further validated this association using data from the National Health and Nutrition Examination Survey (NHANES) database (2005-2020 cycles). This retrospective study enrolled 718 RA patients from the Rheumatology Department of the First Affiliated Hospital of Guangzhou University of Chinese Medicine between January 2020 and December 2024. Patients were categorized into low-NPAR (<1.7598) and high-NPAR (≥1.7598) groups based on the median NPAR. Extracted clinical data encompassed demographic characteristics, comorbidities, serological markers, and other laboratory parameters. Preliminary univariate and multivariate logistic regression analyses assessed potential associations between NPAR and RA-OP, multi-model adjusted logistic regression was subsequently applied to evaluate the independent association, subgroup analyses examined consistency across demographic and clinical strata, Receiver operating characteristic (ROC) curve analysis assessed NPAR's diagnostic performance, and then Restricted cubic splines (RCS) visualized potential non-linear relationships. Fin...