Palladium-Catalyzed Suzuki–Miyaura Couplings of Glycal Boronates with Aryl Thianthrenium Salts for the Synthesis of C -Aryl Glycals

作者：Yufan Zhang, Chengyang Guan, Mingjie Zeng, Qian Wang, Hong Liu, Jiang Wang · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c03390 · 被引用次数：4 · 研究领域：Carbohydrate Chemistry and Synthesis、Chemical Synthesis and Analysis、Catalytic Cross-Coupling Reactions

Aryl C -glycosides represent key structure motifs in numerous natural products and pharmaceuticals. Here, we report a palladium-catalyzed Suzuki–Miyaura cross-coupling reaction between glycal boronates and aryl thianthrenium salts under mild conditions, enabling the synthesis of C -aryl glycals. This method features broad substrate scope, excellent functional group tolerance, and operational simplicity. Furthermore, the synthetic utility of this strategy is demonstrated through late-stage functionalization of structurally complex drug molecules, underscoring its potential for medicinal chemistry applications.