NIR-Ⅱ Luminescent Probes for Bioimaging

作者：Ping Du, Xiaohan YANG, Xiao He, Ling‐Dong Sun · 发表于：Chinese Journal of Luminescence · 年份：2025 · DOI：10.37188/cjl.20250130 · 被引用次数：6 · 研究领域：Nanoplatforms for cancer theranostics、bioluminescence and chemiluminescence research、Analytical Chemistry and Sensors

Abstract： Optical imaging in the second near-infrared window (NIR-Ⅱ ， 1 000-2 000 nm) significantly improves in vivo imaging depth and resolution by reducing tissue scattering and autofluorescence.Over the past decade， the development of diverse NIR-Ⅱ probes and imaging setups has enabled NIR-Ⅱ imaging to overcome the penetration depth limitations of conventional optical techniques， achieving cross-scale dynamic observation from macroscopic an• atomical structures to microscopic molecular events， thereby providing revolutionary tools for biomedical research.This review systematically summarizes recent advances in the design of NIR-Ⅱ luminescent probes and their biomedi• cal applications.The optical properties of various NIR-Ⅱ probes are discussed， with a focus on their innovative ap• plications in anatomical structure imaging， precision tumor diagnosis and therapy， real-time tracking of molecular events in vivo， responsive imaging， microenvironment visualization， and the construction of integrated theranostic platforms.Finally， critical summaries and perspectives on the development and applications of NIR-Ⅱ luminescent materials are presented， highlighting their potential for broader impacts in fundamental research and clinical translation.