In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus

作者：Qian Wang, Ze Xiu Xiao, Xu Zheng, Guihong Wang, Linlin Yang, Lina Shi, Nan Xiang, Xingbing Wang, Gao‐Feng Zha, G. Schett, Zhu Chen · 发表于：New England Journal of Medicine · 年份：2025 · DOI：10.1056/nejmc2509522 · 被引用次数：140 · 研究领域：CAR-T cell therapy research、Viral Infectious Diseases and Gene Expression in Insects

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxic effects.