IQGAP1: cross-disease target via receptor-pathway networks

作者：Shaopeng Zhu, Yunpeng Zou, Jie Guo, MA Wen-qi, Liwei Lu, Ronghan Liu, Jianning Kang, Kai Zhao, Jiangbo Zhong · 发表于：Frontiers in Oncology · 年份：2025 · DOI：10.3389/fonc.2025.1632060 · 被引用次数：5 · 研究领域：CRISPR and Genetic Engineering、Cellular transport and secretion、Endoplasmic Reticulum Stress and Disease

IQGAP1, a versatile scaffolding protein, critically regulates cytoskeletal organization, cell motility, proliferation, and signaling cascades. Beyond coordinating these cellular functions, it is increasingly recognized as a key driver in malignancies, immune dysfunction, metabolic dysregulation, and cardiovascular pathologies. By binding receptor tyrosine kinases, small GTPases, and downstream effectors, IQGAP1 modulates oncogenesis, immune evasion, and metabolic imbalance, while contributing to chemoresistance. This review synthesizes advances in IQGAP1's structural domains, disease-specific signaling networks, and therapeutic targeting strategies, emphasizing its translational potential in developing precision therapies for cancer, metabolic syndromes, and immune disorders.