1H-MRSI of the Deep Gray Matter Nuclei in Patients With Amyotrophic Lateral Sclerosis

作者：Arda Canbaş, Gökçe Hale Hatay, Meryem Torlak, Barış İşak, Alpay Özcan, Dilaver Kaya, Alp Di̇nçer, Esin Öztürk-Işık · 发表于：Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · 年份：2025 · DOI：10.58530/2025/2986 · 研究领域：Neurological disorders and treatments、Amyotrophic Lateral Sclerosis Research、Genetic Neurodegenerative Diseases

Motivation: There is a need to define early biomarkers of amyotrophic lateral sclerosis (ALS) by investigating metabolic differences in patients with distinct regional onsets. Goal(s): Identify specific metabolic differences among ALS patients based on their regional and limb onsets. Approach: 1H-MRSI data from deep gray matter nuclei of 29 ALS patients were quantified using LCModel and compared between different onset groups. Results: Lumbosacral onset patients showed higher tNAA/tCr and Tau/tCr in white matter than cervical onset patients. ALS patients had elevated Glu/tCr in the left putamen for the left onset and in the right caudate for the right onset. Impact: This study demonstrated that alterations in tNAA/tCr, Tau/tCr, and Glu/tCr ratios could enhance the understanding of ALS pathophysiology in distinct regional and limb onset groups and potentially contribute to future treatment planning.