Lung Ventilation-Perfusion Imaging Approaches in the Single Ventricle Heart

作者：Eamon Doyle, Ecrin Yağız, Sophia Cui, Jon Detterich, R. Kato, Krishna S. Nayak · 发表于：Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · 年份：2025 · DOI：10.58530/2025/0912 · 被引用次数：1 · 研究领域：Atomic and Subatomic Physics Research、Ultrasound and Hyperthermia Applications、Advanced MRI Techniques and Applications

Motivation: Techniques have been developed to conduct non-invasive lung ventilation and perfusion imaging with MRI. In single ventricle patients, their pulmonary blood flow is non-pulsatile, so it is unknown if these techniques will work in this patient population. Goal(s): To investigate whether new ventilation/perfusion techniques work in absence of pulsatile lung blood flow seen in single ventricle subjects. Approach: We imaged human subjects with normal and single ventricle hearts and post-processed the data through two ventilation-perfusion pipelines to assess feasibility. Results: The normal subjects demonstrate similar ventilation and perfusion patterns in both pipelines. Single ventricle subjects demonstrate similar ventilation maps but differing perfusion maps. Impact: These results will help to determine which imaging approaches work best for patients with single ventricle heart defects, which will provide functional information for research and clinical use.